Canine Distemper Virus

Premal Darji has ne1 ever taken blood samples in dog with distemper..can u suggest what were the findings in terms of PCV, Hb, Neutro, Lympho, RBCs, WBCs.what changes commonly seen in series of bllod tests in different dogs..want it just for my refrence..

10 July at 12:02 · Comment · · Flag

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    Rajshankar Tony Sarma

    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WWR-4M877JX-1&_user=10&_coverDate=06%2F30%2F2007&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor&view=c&_searchStrId=1402835127&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=af970a937e0c339d864456308d69be69
    
    Am trying to get hold of the paper!

    16 July at 22:34 · ·
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    Rajshankar Tony Sarma

    From that paper...
    
    The abnormalities found in the hematologic examination could not be used to suggest the CDV infection since they were also frequent in the group used for comparative purpose. In experimentally infected animals, frequent hematologic findings are lymphopenia, sometimes associated with leukopenia or leukocytosis with left shift, anemia, and rarely thrombocytopenia. Several hematologic abnormalities have been reported in natural occurring distemper encephalomyelitis, however they are frequently absent or non-specific in naturally infected dogs.
    
    Although the literature claim that the acute CDV encephalomyelitis takes place during severe immunosup- pression, ours dogs suffering from acute demyelination (n = 2) were not lymphopenic. Chronic CDV lesions coincide with recovery of the immune system (Vandevelde and Zurbriggen, 1995), nevertheless 3 out of 5 dogs suffering from chronic encephalomyelitis were lymphopenic.
    
    In our investigation 100% (8/8) of the cases with the post mortem diagnosis of distemper were presented with lymphocytic pleocytosis. This finding was found in only 33.3% (4/12) of the dogs from the group used for comparative purpose. Lymphocytic pleocytosis (>5 cells/ll) may suggest the diagnosis of CDV infection, however, not all dogs infected with CDV will have changes in CSF. Nevertheless, others inflammatory diseases of the CNS may be presented with lymphocytic pleocytosis.

    16 July at 22:39 · ·
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    Premal Darji thnks doc for that information...

    17 July at 15:43 · ·