Fatty liver disease

Manish Kumar a labrador of mixed breed having age 1.5 years,overweight-more than 40 k.g. feeling letherginess after walk n unable to stand after tht.stomach become tight....here i am giving his blood report
HB-20.8,PCV-62.1,NEUTROPHILS-23,LYMPHOCYTES-73,RBC-9.24 MILLIONS,PLATLET COUNT-1.88,SERUM CHOLESTEROL-262MG/DL,SGOT-92,SGPT-84,,CREATININE-1.1,ALKALINE PHOSPHATASE-456IU/L.PLZ SUGGEST WAT COULD B D MOST PROBABLE DISEASE N LINE OF TREATMENT....

21 July at 10:45 · Comment · · Flag

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    Nassem N. Naimi what are the normal rates

    21 July at 11:15 ·
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    Swarupmay Majumdar Its complicated.........

    21 July at 15:26 ·
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    Saurabh Saxena its really very tricky.neutropenia can be due to viral infection,endotoxin ingestion or bone marrow aplasia(very rare).wud suggest to check from different lab though. hb @20 with viral infection is sumthg i have not seen b4?

    21 July at 15:38 · · 1 person
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    Manish Kumar tht's why i m here...i am suspecting fatty liver disease...but i kw senior vets can help me..
    @

    21 July at 15:57 ·
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    Sp Singh try other lab and do investigate the liver further----di inform

    21 July at 16:32 ·
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    Rajshankar Tony Sarma Need reference ranges unfortunately. PCV seems high unless particularly dehydrated (need ref ranges for urea, crea, TP to compare).

    21 July at 16:48 ·
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    Sp Singh yes ,pcv is high and radiography may help further

    21 July at 16:56 ·
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    Manish Kumar dr. unny plz give sm suggestion...

    21 July at 19:16 ·
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    Rajshankar Tony Sarma If you're thinking fatty liver, ultrasound plus biopsy. Radiography good for abdominal survey and to confirm hepatomegaly, ultrasound for hepatic ultrastructure. However, again - am jumping the gun as I don't actually know which of the parameters you've listed are abnormal, and by how much. Do we have urinalysis too?

    21 July at 19:56 ·
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    Manish Kumar i hv listed only abnormal parameters..HERE I AM GIVING NORMAL VALUES--- HB(12-18),PCV-37-55,NEUTROPHILS-60-77,LYMPHOCYTES-12-30,PLATLETS-200-500 ,TLC-6000-17000,SGOT-5-55,SGPT-5-60,ALAK.PHOSPHATASE-10-150,,CHOLESTEROL-112-32 ETC..I HV NOT DONE URINALYSIS

    22 July at 10:58 ·
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    Rajshankar Tony Sarma

    First off - what clinical signs other than lethargy? Why was dog brought in? What physical signs - are we talking abdo guarding or full-on severe abdo pain (if pain++++ with V/D, have we thought pancreas - ck lipase, TLI, ideally cPLI)
    
    Right. Haematology is interesting - PCV up, low neutrophils and high lymphocytes. Smear needed there - what is morphology of cells? PCV increases usually dehydration, ideally want to compare to total protein and BUN/urea, the use urine SG to consider whether kidney function is adequate. Platelet count of 1.88 (200-500) is incompatible with life - either this is spurious or should be 188??
    
    Creatinine - no ref range yet - if elevated need to repeat crea and urea and do a simultaneou USG to work out if renal, prerenal or postrenal elevation.
    
    Any dog which is non-specifically lethargic but ill enough to deserve biochemistry - do electrolytes (Na / K / Cl).
    
    Need to be careful here - there are few specific leads here, we are in danger of overdiagnosing this dog as we are looking solely at a few blood parameters and have far less info about the dog and its clinical status. A discussion of that would be good
    
    ALKP and AST (SGOT) increases - sadly, not specific - has dog been on any meds? E.g. steroid will increase ALKP easily to this level. AST also influenced by myocardial disease so rule that out too. May be liver involvement and biliary disease - what is TBil? Are there signs of Vomiting, Diarrhoea, PUPD, weight changes, appetite alterations etc. etc.? Cannot be interpreted without clinical findings unfortunately. IF clinical signs of hepatic disease then this may be a lead, but be careful about over-diagnosing these if not. Next stage for liver workup - bile acid stimulation test to confirm whether liver is functionally compromised or simply reactive, and imaging as discussed - ultrastructural view require sonography/biopsy.

    22 July at 11:18 ·
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    Joseph Cyrus i would recommend that you do a DLC. I am sure that a human lab was used. Blood glucose?

    22 July at 17:56 ·