Organochlorurates toxicity in rabbits

Swarupmay Majumdar I'm wondering is there any antidote for GBH -gamma benzine hexachloride or lorexane or lindane ! I am seeing a rabbit which is been prescribed 1% Lindane/scabidol for ear by a vet suspecting scabies. GBH causes acute poisoing in Rabbits. lethal dose through dermal application is around 300mg/kg. the rabbit has been going through continous fits, tremors and teeth grinding since morning, after a gap of 12 hrs of application. We have stated on drips, rantac, bcomplex, cleaning ear in plain shamppoo, and T. gardenal. just wondering , whether we can use gardenal actaully and if there are any antidote for GBH.

01 June at 14:58 · Comment · · Flag

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    Nassem N. Naimi Diazepam 1mg/kg IV the only thing to use clinical sign according to human reports may take 48h to resolve.
    I believe fluid therapy(N.S.) wont be bad as GBH may affect kidney and liver

    01 June at 16:03 ·
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    Swarupmay Majumdar yes, we have put the rabbit on Diazepum. adv using per rectum every 12 hrs. been on drips as he was not eating anythin. still worried whether he will survive.

    02 June at 09:44 ·
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    Nassem N. Naimi I didn't find any animal case only 3 human cases and all resolved after supportive therapy within 48 hours!

    02 June at 16:09 ·
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    Swarupmay Majumdar the rabbit survived...I must say, rabbit, rabbit 123, will u come and play with me

    03 June at 09:48 ·
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    Nassem N. Naimi hehehehe Yea I have that kind of happiness when I difficult case survive I start singing stupid kids songs :P

    03 June at 09:54 ·
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    Joseph Cyrus congrats. why lindane? why not ascarbiol, u should tell the other vet for his infomation sake!

    07 June at 17:34 ·
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    Swarupmay Majumdar Vets do not like advices by other vets except a few exceptions like those who puts cases here on regular basis. If any one comments or questions not in favour most vets even turn back to the group. thats the reality. I want to inform the vet, but I dont know I can ever do that, becoz I fear hurting their sentiments.

    08 June at 11:33 ·
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    Elena Madgliani keep it up protecting his feelings... you should care a little more for the life of the animal then the feelings of a fellow vet ..who...in the right mind would thank you for a good advice

    08 June at 19:18 ·
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    Nassem N. Naimi but if the advice will be useless and he wont listen and you will just get harness out of the advice I believe staying in the safe side is better

    08 June at 19:21 ·
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    Elena Madgliani

    the treatment for all OCl is:
    izolating the animal and keeping it away from any source of excitement, even bright light, noise ..every source of stress, saline purgatives (not oily ones because they act in favor of the toxic), Ca gluconate iv - stops the liver damage; barbiturics to calm the animal; activated charcoal (depending of the route that the toxic entered the animals body),
    the thing to take care is that OCLs are stuck in the fatty tissue so if the animal, even 3 moths later happends to loose weight those cells will be used and then you can aspect a relaps with no present cause...

    08 June at 19:27 ·
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    Museed Anwer do lindane has toxic effects on cats?
    

    08 June at 21:57 ·
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    Swarupmay Majumdar ‎@Museed: it causes acuse toxicity with signs like tremors, seizures , teeth grinding in cats also as per books, not seen a case yet. but when applied orally or over a big surface area.
    

    09 June at 11:32 ·
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    Swarupmay Majumdar ‎@elena: nice .thanks

    09 June at 11:32 ·
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    Museed Anwer thanks

    09 June at 11:59 ·
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    Joseph Cyrus i agree with elena hell with vets sentiments, save the animals life! we have a resonsibility to them!

    09 June at 15:54 ·